Immunohistochemistry Kits and Reagents
ABclonal Technology IGF2BP1/IMP1 Rabbit pAb
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
Abcam Hydrogen Pero x ide Blocking Reagent, 60ML
Hydrogen peroxide blocking reagent is used to block endogenous peroxidase activity in IHC applications, enhancing signal detection in HRP / peroxidase-based systems. - Cited in over 30 publications - Endogenous peroxidase block – prevents non-specific background staining in IHC - HRP-based detection – ideal for use with HRP/peroxidase detection systems - Concentration – contains 0.3% hydrogen peroxide
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Recombinant rat discoidin domain receptor 1 (DDR1) protein, His-tag | >95.0% | 50 UG
Recombinant rat discoidin domain receptor 1 (DDR1) is supplied as a His-tagged protein produced in HEK293 cells, covering residues M1-T413 (accession Q6MG19). It is intended for research use in biochemical and cell-based studies involving DDR1 signaling and binding.
- Recombinant protein expressed in HEK293 for native-like mammalian post-translational modifications.
- His-tagged for facile purification and detection.
- Includes residues M1-T413 to represent the functional receptor region.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Available in small research quantities suitable for assay development.
Biotium Cytokeratin 8/18(KRT8/803 + KRT18/835), CF740 conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). This MAb cocktail recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. This antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained.Immuno-histochemical staining with this MAb is indistinguishable from that obtained with monoclonal antibody 5D3.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF
Cell Signaling Technology FoxP3/Transcription Factor Fixation/Permeabilization Concentrate (4X) 50 ml
FoxP3/Transcription Factor Fixation/Permeabilization Concentrate (4X) 50 ml
Meso Scale Discovery V-PLEX Plus Human ICAM-1 Kit
The Meso Scale Discovery K151SUG-4 is a 4-plate assay kit for measuring glucose in biological samples It uses electrochemiluminescent detection technology for high sensitivity and wide dynamic range The assay takes 2 5 hours and requires 25 L of sample per well It can detect glucose in the range of 0 03-1000 g/mL The kit includes plates coated with glucose oxidase calibrators controls detection antibody read buffer wash buffer and plate seals It is designed for research use only
Biotium Cytokeratin 8 (KRT8)(KRT8/2115), CF568 conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular ('ring-like, perinuclear') from ductal ('peripheral-predominant')
Cayman Chemical DDR1-IN-1hydrate 5mg
A selective DDR1 inhibitor (IC50 = 105 nM; EC50 = 87 nM; inhibits colorectal cancer cell lines when used in combination with the PI3K/mTOR inhibitor, GSK2126458
Abcam DoubleStain IHC Kit: R&Rt on human/mouse tissue (Green/HRP & AP/Red), 18ML
Abcam's Doublestain IHC Kit (ab183285) is designed for use with user supplied rabbit and rat primary antibodies to detect two distinct antigens on human and mouse tissue or cell samples.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology PDK1/PDHK1 Rabbit pAb
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.
Biotium CD2(BH1), CF594 conjugate, 0.1mg/mL
CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abunda
ABclonal Technology Phospho-p38 MAPK-Y182 Rabbit pAb
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Biotium S100B(S100B/1012), CF594 conjugate, 0.1mg/mL
S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. This antibody is specific against an epitope located on the beta-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0). This antibody can be used to localize S-100A and S-100B in various tissue sections. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and case
Cole-Parmer COLE-PARMER 0.01 TO 100 MTORR
Cole-Parmer 0.01 To 100 mTorr Pressure/vacuum Pirani-Type Sensor, 3/4" Tube OD